OneTest™ for Workplace Wellness

The Smarter Way to Reduce Healthcare Costs, Cut Absenteeism, and Build a Healthier, More Productive Workforce

Chronic inflammation is one of the most costly, overlooked drivers of poor employee health—and it silently fuels many of the conditions that drain productivity, increase absenteeism, and inflate healthcare spending. OneTest™ for Workplace Wellness gives employers a powerful, science‑backed way to identify inflammation early, guide employees toward healthier habits, and generate measurable improvements in workforce well‑being within just 8–12 weeks.

Why OneTest™?

OneTest for Workplace Wellness is likely the first program that combines each of the following components: 

  1. A panel of key inflammatory and cardiometabolic biomarkers that can be measured from upper arm   capillary blood collected at the workplace or at home without the need for phlebotomists; 
  2. A unique and proprietary food frequency questionnaire developed and refined over many years (with millions of dollars in competitive, peer-reviewed NIH funding) to capture key dietary patterns; and 
  3. AI powered algorithms, developed by a team lead by veterans of IBM, that incorporate thousands of curated peer-reviewed scientific publications on health, diet and inflammation.   These algorithms analyze and integrate the biomarker levels, results of the food frequency questionnaire, and the literature to offer individualized, evidenced base “dietary nudges” to lower lab values and associated disease risk

Biomarkers

Workplace Impact 

HS-CRP 

Measures systemic inflammation linked to most chronic diseases as well as fatigue, brain fog, and mood disorders. 

TNF-alpha 

Detects systemic inflammation associated with joint pain and depression. 

IL-6 

Linked to stress, poor diet and most chronic diseases 

LDL / TG 

Elevated levels contribute to metabolic syndrome and potential for heart disease. 

HbA1c 

Tracks long-term glucose control; high levels impair cognition and energy. 

Ferritin 

Low levels cause fatigue; high levels may indicate inflammation. 

Vitamin B12 / D 

Deficiencies impair cognition, mood, and immune resilience. 

TSH 

Thyroid dysfunction affects energy, weight, and mental clarity. 

Uric Acid / Homocysteine 

Elevated levels linked to oxidative stress and vascular damage. 

Financial Impact & ROI Calculation Model

Estimated Cost: Assuming a volume discount of approximately $95 per test, for employers ordering testing for at least 15,000 employees on a quarterly basis, the total expenditure for 15,000 employees would be $380 per employee per year or a total of $5.7 million annually.

Cost Savings Model

1. Baseline Healthcare Costs

    • According to the Kaiser Family Foundation, the average annual healthcare cost per employee in a self-insured plan is $7,739 (2023 data). 
    • For 15,000 employees: = $116,085,000 \ per year 

2. Financial Savings

    • Direct Cost Reductions from Lifestyle Interventions
      • Studies from the American College of Lifestyle Medicine and Vital Incite show that comprehensive lifestyle programs (including biomarker feedback and personalized coaching) can reduce health insurance claims by 10–25% over time American College of Lifestyle Medicine;  arXiv.org. 
      • Model for three scenarios:
        • Conservative (10%): 
          0.10 x $116,085,000 = $11.61 million saved annually.
        • Moderate (15%): 
          0.15 x $116,085,000  = $17.41million saved annually
        • Aggressive (25%): 
          0.25 x $116,085,000  = $29.02  million saved annually.
      • Indirect Cost Reductions from Improved Employee Productivity, Morale and    Reduced Absenteeism  

Reducing chronic inflammation—especially through biomarker-guided lifestyle interventions—can yield substantial additional value to employers beyond direct healthcare savings. Here’s a breakdown of how it affects absenteeism, morale, and productivity, with supporting data: 

Absenteeism Reduction 

  • According to the CDC, employees with chronic diseases (including diabetes and hypertension, both inflammation-linked) miss 1.5–2 more days per month than healthy peers CDC. 
  • A reduction in inflammation-related conditions could conservatively reduce absenteeism by 1 day/month per affected employee. 
  • For a company with 15,000 employees participating in the program, assuming 30% have one or more chronic diseases: 4,500 missed days per month or x 12 per year x $300 average daily productivity (based on data from the Bureau of Labor Statistics adjusted for a typical Fortune 500 company) = $16.2  million/year.   

Productivity Gains 

  • A study by MY Dr’s Note found that frequent illness and inflammation-related fatigue can reduce productivity by 15–20% mydrsnote.com. 
  • If even 10% of the 15,000 participating employees improve productivity by 10%, the gain is: 1,500 employees x $75,000 {avg. salary} x10% = $11.2 million/year.   

Mental Health & Inflammation: The Hidden Link 

  • Chronic inflammation is now recognized as a biological driver of depression and anxiety. Inflammatory cytokines disrupt neurotransmitters like serotonin and dopamine, impair neuroplasticity, and activate the HPA axis—all of which contribute to mood disorders Psychology Today. 
  • Anti-inflammatory interventions (diet, exercise, sleep) have shown promise in reducing depressive symptoms, especially in individuals with elevated CRP or IL-6, two of the biomarkers measured and tracked with this test.  Psychology Today. 

Improved Morale & Engagement 

  • Wellness programs that reduce inflammation (via diet, sleep, and stress management) have been shown to:  
  • Increase employee satisfaction scores by 10–20% 
  • Reduce turnover rates by 15–25% 
  • Improve self-reported energy and focus

3. Program Cost Estimate

Assuming quarterly testing, dietary assessment, reporting, analytics, and digital coaching costs $95 per employee per quarter (including lab tests, FFQ, and digital coaching): 

  • Annual cost per employee: 
    4 x 95 = $380 
  • Total annual program cost: 
    15,000x 380 = $5.7 million 

4. Net Savings (Direct) 

Scenario 

Gross Savings 

Program Cost 

Net Savings 

Direct  

Indirect 

Conservative 

$11.61M 

$27.4 

$5.7M 

$39.01M 

Moderate 

$17.41M 

$27.4 

$5.7M 

$44.81M 

Aggressive 

$29.02M 

$27.4 

$5.7M 

$56.42M 

This calculated ROI of at least 584% (i.e., for every dollar spent employer gains about $5.84 in savings) is in line with ROI’s reported in studies of wellness programs at diverse companies.  A meta-analysis from Harvard looking at more than 30 studies on employee wellness ROI found that medical costs fall by about $3.27 for each dollar spend and absenteeism costs fall about $2.73 per wellness dollar spent.  See Workplace wellness programs can generate savings – PubMed.

Johnson & Johson claimed that their employee wellness program yielded about $2-$4 for each dollar spent on the program.  

Key Assumptions 

  • At least 60–70% participation and moderate adherence to recommendations. 
  • Savings accrue over 12–24 months, with compounding benefits. 
  • Biomarker feedback meaningfully influences behavior (as supported by studies on biological feedback and digital health platforms). 
To pilot OneTest for Workplace Wellness at your company, contact: WorkplaceWellness@2020Biolabs.com